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Driven by recent evidence and current uncertainties in practice

31 Ocak 2013
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Although the interactive effect of steroids and bronchodilators has emerged as a potential treatment option,16 it has not been examined at the level of systematic review and placed in the context of other evidence.Driven by recent evidence and current uncertainties in practice, we systematically evaluated and compared the efficacy and safety of bronchodilators (2 agonists, adrenaline, anticholinergics) and steroids, alone or combined, for the acute management of bronchiolitis. We also determined the effectiveness of steroids with a fixed protocol for bronchodilator use compared with those in which the bronchodilator was given at the discretion of the attending physician, and bronchodilators given with and without steroids. By carrying out mixed treatment comparisons, we sought to improve on previous systematic reviews that focused primarily on pairwise, direct comparisons, often with the comparator being a placebo.Search strategyA medical research librarian searched Medline Ovid version (1950 to November week 2 pandora jewellery, 2009), Embase Ovid version (1980 to 2009 week 47), EBM Reviews Cochrane Central Register of Controlled Trials (4th quarter 2009), LILACS Latin American and Caribbean Center on Health Sciences Information (25 November 2009), PubMed (9 March 2009), Scopus (1823 to 25 November 2009), and IranMedEx (26 November 2009).

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